Myopathy with Concurrent Tadalafil and Simvastatin

Myopathy with Concurrent Tadalafil and Simvastatin

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A 48-year-old man, using lifewalker upwalker statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin.Muscle pain and penile erection disappeared seven days after interruption of therapy.This case demonstrates the interaction of tadalafil with simvastatin resulting 220.10.38.20.02.001 in myopathy.Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.